| Date | Location | Result | |
| Nov 05, 2021 | Richmond KY | MADISON CENTRAL 42, Oldham County 9 | Box score |
| Oct 29, 2021 | Somerset KY | Southwestern Pulaski 26, MADISON CENTRAL 0 | Box score |
| Oct 22, 2021 | Richmond KY | Bryan Station 21, MADISON CENTRAL 13 | Box score |
| Oct 15, 2021 | Winchester KY | MADISON CENTRAL 43, George Rogers Clark 7 | Box score |
| Oct 08, 2021 | LaGrange KY | MADISON CENTRAL 31, Oldham County 15 | Box score |
| Oct 01, 2021 | Richmond KY | MADISON CENTRAL 21, Pikeville 19 | Box score |
| Sep 17, 2021 | Lexington KY | MADISON CENTRAL 49, Lafayette 0 | Box score |
| Sep 10, 2021 | Unknown | MADISON CENTRAL 69, SOUTH LAUREL 6 | Box score |
| Aug 27, 2021 | Lexington KY | MADISON CENTRAL 34, Paul Laurence Dunbar 24 | Box score |
| Aug 20, 2021 | RICHMOND, KY | LEXINGTON CHRISTIAN 21, MADISON CENTRAL 12 | Box score |