| Date | Location | Result | |
| Nov 05, 2021 | PLD | PAUL LAURANCE DUNBAR 21, LAFAYETTE 19 | Box score |
| Oct 22, 2021 | Lafayette High | PAUL LAURANCE DUNBAR 34, LAFAYETTE 14 | Box score |
| Oct 15, 2021 | TCHS | TATES CREEK 42, LAFAYETTE 6 | Box score |
| Oct 07, 2021 | Lexington, Ky. | LAFAYETTE 35, HENRY CLAY 20 | Box score |
| Oct 01, 2021 | Winchester, Ky. | LAFAYETTE 14, GEORGE ROGERS CLARK 3 | Box score |
| Sep 24, 2021 | LEXINGTON, KY | BRYAN STATION 43, LAFAYETTE 0 | Box score |
| Sep 17, 2021 | Lexington KY | Madison Central 49, LAFAYETTE 0 | Box score |
| Sep 10, 2021 | BEREA, KY | MADSOUTH 23, LAFAYETTE 19 | Box score |
| Sep 03, 2021 | LEXINGTON, KY | DOUGLASS 50, LAFAYETTE 0 | Box score |
| Aug 27, 2021 | Lafayette High | SCOTT COUNTY 41, LAFAYETTE 0 | Box score |
| Aug 20, 2021 | Lexington, Ky. | CONNER 35, LAFAYETTE 12 | Box score |