| 2021 Ohio Valley 12 Major 70 Regional -- Game Schedule | ||||||||||
| Field 1 | Date | Time | Team | Team | Field 3 | Date | Time | Team | Team | |
| 12OV01 | 7.22.21 | 10am | Fern Creek-Lou., Ky. | Southeastern-Host | 12OV02 | 7.22.21 | 10:30am | Mattoon, Il. | Elizabethtown, Ky. | |
| 12OV03 | 12pm | Kokomo, In. | Fairfield, Oh. | 12OV04 | 12:30pm | Germantown-Lou., Ky. | Lawrence Co. Il. | |||
| 12OV05 | 2pm | Elizabethtown, Ky. | South Lexington, Ky. | 12OV06 | 2:30pm | Larue Co., Ky. | Mattoon, Il. | |||
| 12OV07 | 4pm | Campbellsville, Ky. | Germantown-Lou., Ky. | 12OV08 | 5:30pm | Barren Co., Ky. | Lawrence Co. Il. | |||
| 12OV09 | 6pm | Southeastern-Host | Kokomo, In. | |||||||
| 12OV10 | 7.23.21 | 10am | Larue Co., Ky. | South Lexington, Ky. | 12OV11 | 7.23.21 | 10:30am | Fern Creek-Lou., Ky. | Fairfield, Oh. | |
| 12OV12 | 12pm | Barren Co., Ky. | Germantown-Lou., Ky. | 12OV13 | 12:30pm | Lawrence Co. Il. | Campbellsville, Ky. | |||
| 12OV14 | 2pm | Fern Creek-Lou., Ky. | Kokomo, In. | 12OV15 | 2:30pm | South Lexington, Ky. | Mattoon, Il. | |||
| 12OV16 | 4pm | Larue Co., Ky. | Elizabethtown, Ky. | 12OV17 | 5:30pm | Barren Co., Ky. | Campbellsville, Ky. | |||
| 12OV18 | 6pm | Fairfield, Oh. | Southeastern-Host | |||||||
| 12OV19 | 7.24.21 | 10am | Kokomo, In | Elizabethtown, Ky. | ||||||
| 12OV20 | 7.24.21 | 12pm | Germantown-Lou, Ky | Campbellsville, Ky. | ||||||
| 12OV21 | 7.24.21 | 2pm | Southeastern-Host | Elizabethtown, Ky. | ||||||
| 12OV22 | 7.24.21 | 4pm | South Lexington, Ky | Campbellsville, Ky. | ||||||
| 12OV23 | 7.25.21 | 11am | South Lexington, Ky | Southeastern-Host | ||||||
| Champions | ||||||||||